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Chloroquine and other aminoquinolines are used in the prophylaxis of or therapy for malaria and other parasitic diseases. Chloroquine and hydroxychloroquine also are used in the treatment of rheumatoid arthritis.


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Drugs in this class include chloroquine phosphate Aralen , amodiaquine hydrochloride Camoquin , hydroxychloroquine sulfate Plaquenil , mefloquine Lariam , primaquine phosphate, and quinacrine hydrochloride Atabrine. Quinine toxicity is described in Quinine. Hydroxychloroquine has similar actions but is considerably less potent.

Primaquine and quinacrine are oxidizing agents and can cause methemoglobinemia or hemolytic anemia especially in patients with glucosephosphate dehydrogenase [G6PD] deficiency. The terminal half-life of chloroquine is 2 months, and that of hydroxychloroquine is 40 days. Primaquine, with a half-life of 3—8 hours, is extensively metabolized to an active metabolite that is eliminated much more slowly half-life of 22—30 hours and can accumulate with chronic dosing see also Table II— Toxic dose. The therapeutic dose of chloroquine phosphate is mg once a week for malaria prophylaxis or 2.

Clinical presentation Mild to moderate chloroquine overdose results in dizziness, nausea and vomiting, abdominal pain, headache and visual disturbances sometimes including irreversible blindness , auditory disturbances sometimes leading to deafness , agitation, and neuromuscular excitability. The use of chloroquine and proguanil in combination is common and is associated with GI and neuropsychiatric side effects, including acute psychosis.

Severe chloroquine overdose may cause convulsions, coma, shock, and respiratory or cardiac arrest. Severe hypokalemia can occur with either chloroquine or hydroxychloroquine and may contribute to arrhythmias. Primaquine and quinacrine intoxication commonly causes GI upset and may also cause severe methemoglobinemia See Methemoglobinemia or hemolysis; chronic treatment can cause ototoxicity and retinopathy. Amodiaquine in therapeutic doses has caused severe and even fatal neutropenia. Mefloquine in therapeutic use or overdose may cause headache, dizziness, vertigo, insomnia, visual and auditory hallucinations, panic attacks, severe depression, psychosis, confusion, and seizures.

Neuropsychiatric side effects generally resolve within a few days after withdrawal of mefloquine and with supportive pharmacotherapy, but occasionally symptoms persist for several weeks. The findings of gastritis, visual disturbances, and neuromuscular excitability, especially if accompanied by hypotension, QRS- or QT-interval widening, or ventricular arrhythmias, should suggest chloroquine overdose.

Chloroquine May Fight Covid-19—and Silicon Valley’s Into It

Hemolysis or methemoglobinemia should suggest primaquine or quinacrine overdose. Specific levels. Chloroquine is usually not detected on comprehensive toxicology screening. Quantitative levels can be measured in blood but Forgot Password?

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Amid coronavirus, a drugmaker rescinds its chloroquine value hike

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Acknowledgements

New York governor Andrew Cuomo has also supported trying the drug because of its positive anecdotal potential, to the point that the state obtained 70, doses and is about to start clinical use trials in New York. There are ways to do that. The new regulation contains an exception for inpatient prescribing. The medication may have saved at least one patient already in the United States.

From a New York Post story:.

He says he was given Benadryl and some other drugs and that when he woke up around a. Giardinieri said doctors believe the episodes he experienced were not a reaction to the medicine but his body fighting off the virus. The post has been corrected. Pixabay Some not bright people tragically poison themselves with a fish-tank cleaner because an ingredient in the compound is similar to those in the anti-malaria drugs that anecdotally have helped people deathly ill with coronavirus. Where to start? From a New York Post story: [Rio] Giardinieri said he contacted an infectious disease doctor about the drug [when his other doctors told him there was nothing they could do].

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Anti-malarial drug is effective in treating patients

Kat Timpf explains why a year-old Maryland girl shouldn't be charged with child-porn distribution after making a video of herself. By Kevin D. Millions of lives and untold trillions in wealth and income may be saved By Therese Shaheen. SARS infected over 8, people worldwide and killed almost Yet post-crisis, China laxly enforced bans on the offending markets, only to permit them to flourish soon thereafter.