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Coronavirus: Chloroquine yields positive data in Covid-19 trial

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Group: antimalarial agent Tablet mg, mg, mg base as phosphate or sulfate Syrup 50 mg base as phosphate or sulfate in 5 ml Injection 50 mg, mg base as phosphate or sulfate per ml in 2-ml ampoule [chloroquine base mg is equivalent to chloroquine sulfate mg or Chloroquine phosphate mg]. Policy regarding the use of this drug as an antimalarial must be determined nationally since in many areas P. It may still be used effectively, however, in areas where low-grade P.

Chloroquine is a 4-aminoquinoline which has marked, rapid schizontocidal activity against blood forms of P. It is also gametocytocidal against P.

It is not active against intrahepatic forms. Absorption is efficient following oral administration and peak plasma concentrations occur within hours.

Coronavirus UK: Potentially effective malaria drug running out

The drug and its metabolites can be detected in the plasma for up to 2 months and in the urine for up to 4 months after a single dose. These forms do not occur in infection acquired congenitally, or from transfusions or other contaminated injections. To avoid nausea and vomiting chloroquine should be administered after meals.

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If part or all of a dose is vomited, the same amount must immediately be readministered. The above regimens are sufficient to eliminate susceptible P. Parenteral administration of chloroquine should be considered when there is no expectation of resistance, when the patient is unable to take drugs orally and when neither quinine nor quinidine is available. Excessively rapid administration results in toxic peak plasma concentrations and a danger of fatal cardiovascular collapse.

Where facilities for intravenous infusion are not available chloroquine can be administered by intramuscular or subcutaneous injection at a dosage of 2.

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This regimen has been employed effectively even in areas of marginal resistance. However, it must be started 1 week before exposure and be maintained until after delivery in pregnant women and for at least 4 weeks after the last risk of exposure in the case of non-immune individuals. This is sufficient to ensure elimination of P. If the condition of the patient deteriorates after administration of chloroquine, resistance must be suspected and quinine must be administered intravenously as an emergency measure.

Could an old malaria drug help fight the new coronavirus?

There is no evidence that chloroquine is harmful in prophylactic doses during pregnancy. Because of the susceptibility of pregnant women to falciparum malaria, it should be used at the recommended dosage for both prophylaxis and treatment wherever chloroquine-sensitive malaria is prevalent. Serious adverse effects are rare at the dosages used for malaria, but pruritus, which may be intolerable, is common among Africans and has also been reported from South and Central America and south-east Asia.